Congratulations to Domenic, who's preprint on the TF ZNF143/ZFP143 has come out in Molecular Cell.
ZNF143 was reported to be a major looping factor that forms chromatin loops either by itself or with CTCF, but Domenic found that this is not the case. Instead, ZNF143 is a transcription factor that binds promoters to activate the expression of some ribosomal and mitochondrial genes. Domenic's paper was co-submitted and co-published with a paper from Elzo de Wit's lab who independently also found that ZNF143 is not a looping factor and was incorrectly assumed to be a looping factor due to a non-specific ZNF143 antibody that cross-reacts with CTCF. Congratulations to Domenic! Comments are closed.
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