Congratulations to James on his new preprint reporting genome-wide absolute quantification of chromatin looping

Congratulations to James on his new preprint in collaboration with Simon, Michele, Pia, and Ilya among our lab and the Zechner, Giorgetti, and Mirny labs. You can find the preprint on BioRxiv.
3D Genomics methods such as Hi-C and Micro-C can identify many thousands of loops across the genome, but all the quantifications are relative. By integrating super-resolution live-cell imaging with Micro-C and new computational methods, James now reports absolute quantification of chromatin loops for the first time (as in, e.g. this loop is present 3% of the time). Across the genome, James finds loops to be generally rare with implications for gene regulation and the mechanisms of enhancer-promoter interactions. Congratulations to James!