We are interested in understanding the interplay between genome organization and regulation of gene expression in mammals. Towards this goal, we develop new experimental and computational tools for following these biological processes inside living cells with single-molecule resolution dynamically over time. And we integrate these approaches with traditional genomic, biochemical and molecular biology approaches. We then apply these tools to understand how genome organization and gene expression is regulated during development and differentiation, and how dysregulation of these processes causes disease, with a particular focus on cancer and developmental diseases. By deciphering the biophysical principles underlying genome organization, our goal is to reach a predictive understanding that will permit computationally-guided de novo design of spatial domains with desired regulatory functions, with applications in synthetic biology. Ultimately, this may allow us to correct genome misfolding in disease.
We are committed to open, robust and reproducible science, where we go after the most important questions in a highly collaborative manner. We are also committed to maintaining an inclusive environment, where everyone feels welcome regardless of background.
