Congratulations to Viraat and Miles on their Region-Capture Micro-C (RCMC) paper being published in Nature Genetics today - you can read the full story here.

By combining region capture with Micro-C, RCMC is able to resolve 3D genome structure at unprecedented depth and helped us uncover new features of the 3D genome.

See also a news story from MIT News by Anne Trafton and a nice 2-min video explainer featuring Viraat and Miles by Melanie Gonick.

Huge congratulations to Harvey on the publication of his DSB preprint in Nature Communications. 

This work in collaboration with former lab member Hugo Brandao asks the question: How do the two DNA ends come back together after a DNA Double-Strand Break (DSB)?

Harvey shows that although this is assumed to just be mediated by passive diffusion, passive diffusion cannot explain the efficiency and kinetics estimated experimentally. Instead, Harvey investigates and proposes a role for loop extrusion in this process.

Check out the full paper here.

Congratulations Harvey!

We are thrilled to welcome Matteo Mazzocca to the lab as a new post-doc.

Matteo recently finished his PhD at San Raffaele University in Italy, working with Davide Mazza. Matteo carried out cutting-edge single-molecule tracking studies of transcription factors with simultaneous readout of chromatin density, to understand the nuclear search mechanism.

Welcome Matteo!

Congratulations to Michele who was awarded a K99 Pathway to Independence Award from the NIH NIGMS, which will support Michele for up to two years more of post-doc and for the first 3 years of his own future lab.
Michele put together an amazing application and received an impact score of 15! Congratulations Michele!

We celebrated several pieces of wonderful unofficial news - Congratulations to Viraat, Miles, and Michele - at the Mad Monkfish with partyboats of sushi.

The lab turned 3 years old on Feb 1, 2023. Time flies. We celebrated by going bowling.