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  • Main
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  • Values
  • Data
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  • Reagents
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Welcome Clarice

3/22/2023

 
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We are thrilled to welcome Clarice Hong to the lab as a new post-doc.

Clarice recently completed her PhD at WashU in St Louis with Barak Cohen in Molecular Genetics and Genomics, where she did some beautiful work using massively parallel reporter assays to understand the genomic environmental effects on core promoters, how gene expression noise is regulated, and the strength of insulators.

Welcome Clarice!

Michele is awarded a K99 Pathway to Independence Award from the NIH

3/18/2023

 
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Congratulations to Michele who was awarded a K99 Pathway to Independence Award from the NIH NIGMS, which will support Michele for up to two years more of post-doc and for the first 3 years of his own future lab.
Michele put together an amazing application and received an impact score of 15! Congratulations Michele!

Celebrating great (unofficial) news

2/17/2023

 
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We celebrated several pieces of wonderful unofficial news - Congratulations to Viraat, Miles, and Michele - at the Mad Monkfish with partyboats of sushi.

Welcome James

2/7/2023

 
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We are thrilled to welcome James Jusuf to the lab.
James joins us from MIT's Biological Engineering graduate program. Prior to that, James received an undergraduate degree in Physics from Caltech and carried out research on gene regulation, synthetic biology, super-resolution microscopy, and much more.

Welcome James!

Happy 3 year birthday to the lab

2/7/2023

 
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The lab turned 3 years old on Feb 1, 2023. Time flies. We celebrated by going bowling.

Congratulations to Asmita and Domenic on the publication of their collaborative paper on PARP particle tracking

1/9/2023

 
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Congratulations to Asmita and Domenic. Our collaborative work investigating the live single-molecule dynamics of PARP1 and PARP2 with and without DNA damage with Jyothi Mahadevan and Karolin Luger is now published in iScience.

Happy new year and congrats to Sarah and Domenic on finishing out the year with fantastic BATS presentations

1/2/2023

 
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A big congratulations to Sarah and Domenic who finished out the year with excellent BATS presentations, presenting their thesis research for the entire department. 

The Micro-C AID paper is now published

12/6/2022

 
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The Micro-C AID paper is now online in Nature Genetics.

Using Micro-C to profile 3D genome structure after acute loss of cohesin, CTCF, WAPL, and YY1, we found that enhancer-promoter interactions are surprisingly robust to these perturbations, at least at short timescales.

This is consistent with enhancer-promoter interactions forming through a (micro)-compartmentalization mechanism as we also found in our recent Region-Capture Micro-C preprint.

We suggest a time-buffering model where CTCF and cohesin may be more important for establishing enhancer-promoter interactions than for maintaining them. Read the full paper at Nature Genetics.

Congratulations to Sarah and Domenic on becoming PhD candidates!

12/6/2022

 
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A big congratulations to Sarah and Domenic who recently passed their Biological Engineering Qualifying Exams with flying colors and have now deservedly earned the titles of PhD candidates - Congrats Sarah & Domenic!

Congratulations to Jamie

10/20/2022

 
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Congratulations to Jamie on the publication of their preview in Molecular Cell.

Jamie previewed an interesting new article from Guo*, Al-Jibury*, Garcia-Millan*, ..., Pruessner, Merkenschlager Chromatin jets define the properties of cohesin-driven in vivo loop extrusion in Molecular Cell that reports the identification of "chromatin jets" - stripes orthogonal to the main diagonal in Hi-C maps, indicative of targeted loading of cohesin at sites.

Chromatin jets provide direct evidence of targeted cohesin loading and helps constrain possible extrusion parameters in vivo.

Check out Jamie's preview here.

And check out the article here.
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