We get a lot of requests for help with Region Capture Micro-C (RCMC) and genome-wide Micro-C, so led by Miles we have put together a comprehensive protocol for both including small adjustments and improvements since our 2023 paper first reporting RCMC. 

Please find the protocol now published in Nature Protocols. 

We also have a GitHub repo with a user-friendly end-to-end computational pipeline for Micro-C and RCMC processing and analysis, which you can find on GitHub. 

A big thank you and farewell to Allison, who is off to Columbia University for graduate school.

We celebrated and said goodbye to Allison with a lab dinner at Five Spices House. All the best for Columbia Allison and come back and visit!

Congratulations to James on the publication of the absolute quantification of looping paper now out in Nature Structural and Molecular Biology.

This has been in collaboration with the Giorgetti, Zechner, and Mirny labs. We now have genome-wide estimates of absolute looping probabilities (e.g. this loop is looped 5% of the time) for the first time. 

See also the very thoughtful News and Views article from Henggeler and Ochs. 

Congratulations to Harvey, Henrik, Jack and also Miles, James, Christos and Jacob on the synEP paper coming online on BioRxiv. This has been a major project and a close collaboration with the Leonid Mirny and Christoph Zechner. 

We attempted to answer the foundational question: How do enhancers and promoters interact in time and space using a synthetic biology approach and our answer is transient contacts. 

You can read the full paper here https://www.biorxiv.org/content/10.64898/2026.06.21.733446v1.full . We celebrated the paper and the summer with a BBQ.

Congratulations to Matteo, Doemnic and Simon on the publication of their MINFLUX paper now out in Nature Structural and Molecular Biology. Thanks also to Jessica Matthias from Abberior for a wonderful collaboration and for all her expertise on MINFLUX and to Tatiana Karpova for hosting us and collaborating at NIH. 

The paper also has a new title since the original preprint which was called Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of Magnitude. 

Thanks also to Anne Trafton for writing a very nice news piece about the paper for MIT News. 

Congratulations to Harvey on the publication of his collaborative paper with the Blobel and Zhang labs, where he contributed key polymer simulations to the study on the cohesin and loop extrusion dependence for reforming enhancer-promoter loops de novo after mitosis. You can read the full paper in Nature Genetics.