Michele Gabriele is joining the lab as a post-doc starting in early 2020. Michele is joining the lab from SEMM - the European School of Molecular Medicine - at the University of Milan, where he worked with Giuseppe Testa on modeling human neurodevelopmental disorders caused by mutations in genes related to chromatin and regulation of gene expression using patient-derived cells.
One of his papers - how YY1 haploinsufficiency can cause intellectual disability - recently resulted in OMIM naming the disease after him: Gabriele-de Vries Syndrome.
We are delighted to have Michele join the lab

Our preprint reporting the absolute quantification of CTCF (~217k proteins per cell) of cohesin (through Rad21; ~109k proteins per cell) in mouse embryonic stem cells has now been published in eLife.
We use these measurements to estimate constraints on models of 3D genome organization: the time-averaged occupancy of an average CTCF binding site is ~50% and the density of putatively loop extruding cohesins is 5.3 per Mb (if monomeric).
We also present biochemical evidence for cohesin-cohesin interactions and we report a very simple, convenient and easy method for absolute abundance quantification of any Halo-tagged protein of interest.
The full paper is here: https://elifesciences.org/articles/40164
And a back-to-back complementary paper in HeLa cells is here: https://elifesciences.org/articles/46269