Huge congratulations to Harvey on the publication of his DSB preprint in Nature Communications. 

This work in collaboration with former lab member Hugo Brandao asks the question: How do the two DNA ends come back together after a DNA Double-Strand Break (DSB)?

Harvey shows that although this is assumed to just be mediated by passive diffusion, passive diffusion cannot explain the efficiency and kinetics estimated experimentally. Instead, Harvey investigates and proposes a role for loop extrusion in this process.

Check out the full paper here.

Congratulations Harvey!

We are thrilled to welcome Matteo Mazzocca to the lab as a new post-doc.

Matteo recently finished his PhD at San Raffaele University in Italy, working with Davide Mazza. Matteo carried out cutting-edge single-molecule tracking studies of transcription factors with simultaneous readout of chromatin density, to understand the nuclear search mechanism.

Welcome Matteo!

Congratulations to Michele who was awarded a K99 Pathway to Independence Award from the NIH NIGMS, which will support Michele for up to two years more of post-doc and for the first 3 years of his own future lab.
Michele put together an amazing application and received an impact score of 15! Congratulations Michele!

We celebrated several pieces of wonderful unofficial news - Congratulations to Viraat, Miles, and Michele - at the Mad Monkfish with partyboats of sushi.

The lab turned 3 years old on Feb 1, 2023. Time flies. We celebrated by going bowling.

Congratulations to Asmita and Domenic. Our collaborative work investigating the live single-molecule dynamics of PARP1 and PARP2 with and without DNA damage with Jyothi Mahadevan and Karolin Luger is now published in iScience.

A big congratulations to Sarah and Domenic who finished out the year with excellent BATS presentations, presenting their thesis research for the entire department.