Huge congratulations to Harvey on the publication of his DSB preprint in Nature Communications.
This work in collaboration with former lab member Hugo Brandao asks the question: How do the two DNA ends come back together after a DNA Double-Strand Break (DSB)?
Harvey shows that although this is assumed to just be mediated by passive diffusion, passive diffusion cannot explain the efficiency and kinetics estimated experimentally. Instead, Harvey investigates and proposes a role for loop extrusion in this process.
Check out the full paper here.
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